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Large study provides new insights in autism’s genetic code

Thursday, February 22, 2007

In the largest study of its kind, a genetic analysis of 1,168 families with multiple cases of autism has identified genetic links to autism. A previously overlooked stretch of DNA on chromosome 11 implicates a gene called neurexin 1 and increases the evidence for the involvement of neurexins and genes related to glutamate transmission in the brain.

Genetic studies of autism have previously been undertaken; however the new study involves the collaboration of more than 120 scientists from more than 50 institutions representing 19 countries who pooled their data as part of the Autism Genome Project. The findings were published in the Feb. 18 issue of Nature Genetics.

Bob Wright, co-founder of Autism Speaks, a non-profit organization dedicated to increasing awareness of autism, said: “The identification of susceptibility genes will provide profound new insight into the basis of autism offering a route to breakthroughs in new treatments in support of families.” Autism Speaks funded this project in conjunction with the U.S. National Institutes of Health.

Joachim Hallmayer, MD, associate professor of psychiatry at Stanford and chair of the collaboration’s executive committee, explains what is next: “While promising, these results need to be followed up with more refined genetic maps to home in on other specific candidate genes. We also need to look more closely at chromosomal anomalies in large samples of children with autism.” In the paper, researchers caution that the genetic foundation of autism probably involves multiple genes and chromosomal abnormalities.

Autism affects about one in every 150 children, and the CDC has called it an “urgent health concern”. Autism is a developmental disorder which impairs social interaction, communication and features restricted and repetitive interests and activities. Twin studies and other research clearly suggest a genetic basis for the condition. Currently there is no cure for autism, but both behavioral or sensory interventions and drugs can influence the symptoms.

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Intellectual Property Is A Useful Tool For Leather Enterprises To Enhance Competitiveness

By Lanbo Jiang

Intellectual property rights are the rights of his or her creative intellectual labor enjoyed exclusive rights, including patents, trademarks, copyrights and other rights. Intellectual property system gives innovators have the legal right to prevent others without the permission of the rights to use, making protection of rights of innovators, a system encouraging innovation. Intellectual property system has been implemented by countries in the world to protect innovation system.

Tool for Market Competition

Science and technology are primary productive forces, the world economy, every major development is the result of technological development to promote, whether national, or enterprise, the first to master the advanced technology, the first to innovation, who will take the forefront in the development. Intellectual property rights as the protection of intellectual innovation, has become an important means of competition in the market.

Intellectual property system gives technology innovators, brand owners in a certain period of time to enjoy the exclusive right to their intellectual products. This right can be called “legal monopoly, winner takes all.” To any other person to use their innovations, brands must be with the agreement and pay the appropriate fees.

Violation of this exclusive community will conduct a variety of legal measures of sanctions, which can effectively stop without innovators, brand owners permission to use innovation law, brand behavior, maintain innovators, brand owners stakeholders.

In order to capture the market, many international companies have increased in China’s patent portfolio. Foreign companies in China commonly used strategy is the first patent monopoly, then the standard monopoly, and then massive occupation of the Chinese market. “International brands in China, the number of patent applications based on the Chinese market, the standard supply and demand, market potential of Chinese enterprises in which large areas in which international brands will seek patent protection, so you can maximize the inhibition of the rise of domestic brands the speed. “State Intellectual Property Office Yang Tiejun, Deputy Secretary pointed out.

[youtube]http://www.youtube.com/watch?v=PXVZXnrpYYM[/youtube]

In recent years, becoming stronger as the awareness of independent innovation and related policies, have made the domestic trademark registration application, utility model patents, design patent applications leapt on board the world’s No. 1 position soon.

However, China’s patent system and intellectual property rights by law enforcement environment, companies will be more to create small applications for the invention and utility model patents, technological level and competitiveness with foreign companies, there is still a large gap.

At present China with independent intellectual property core technology for enterprises of only three ten thousandths, 99% of enterprises do not apply for a patent, 60% of companies do not own the trademarks; Many companies are in a “manufacturing” no “create”, the “property rights “no” knowledge “of the state, some companies even survival depend on imitation and counterfeiting. These are clear to the Chinese patent “Mishap”: quantity, poor quality, competitive patent worrying. The lack of independent core technology of many industrial status, as China’s industrial development and economic construction of the serious constraints.

The Basis of Corporate Brand

As we all know, our traditional manufacturing scale, “China” has long renowned overseas, but no doubt is a traditional manufacturing technology level is not high, lack of independent brands, hard to compete with international brand companies. In particular, a large number of processing enterprises, using relatively cheap labor in China for international brands OEM production, processing fees for modest, the lack of ability to resist risks, and, as China’s economic development, labor, rising income levels, many stickers card processing companies survive difficult to sustain. Faced strong pressure transformation and upgrading.

Leather industry as the traditional manufacturing industry is facing the same problem. Although China’s leather industry output, output ports of the world’s first, is real leather producing countries, but low value-added products, high-end market has long been monopolized by foreign brands.

Industry to sustainable and healthy development must change the mode of development, strengthen independent innovation and brand strategy to improve intellectual property rights. Brand strategy is on the trademarks, trade names (size), goodwill and other intangible assets of the investment, operation and to develop the economy, the development of industry, the development of enterprise management mechanism and competitive strategy.

Specifically, is the brand awareness, striving to well-known brand to brand promotion, and promote industrial development.

Trademark registration is the basis for the implementation of brand strategy. A good logo design does not mean that a good trademark. A good mark in the long-term use, the building has been carefully cultivate, promote, maintain and gradually formed, which are inseparable from the protection of the law. In most countries and regions in the world, the law prior to registration of trade marks are protected by the principle, the same mark, the first to apply for trademark registration to obtain trademark registration, the trademark belongs to whom, the law provided for its registered trademark legal protection.

Worth noting is that trademark protection is a regional, that in a country or region to obtain registration of the mark, only in the country or the region as a trademark protected by law, without obtaining trademark registration in other countries or regions still belongs to an unregistered trademark can not be registered trademarks of legal protection.

Some companies are accustomed to first hit the market, good market prospects see only after the registration of its trademark to apply, but to apply for trademark registration until their own often find their earlier mark has been registered by others, and caused very passive situation.

International Registration of Marks is the first step into the global market in international trade, in order to export their own brands, trademarks must be registered in the country, otherwise, can only OEM for others to do the wedding gown gives way wage, earned by only the low end of industry value chain.

China’s leather industry relies more recent years, more and more Chinese products into the international market, if the brand is registered by experience, would mean the loss of the country (region) of the market. Re-registered trademark, re-create a brand re-enter the country (region), will spend a great price.

About the Author: I am a professional editor from China Products, and my work is to promote a free online trade platform. http://www.himfr.com/ contain a great deal of information about jet black granite,ipaq navigation system,plastic bottle distributor, welcome to visit!

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Ontario Votes 2007: Interview with Green candidate Marion Schaffer, Oakville

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Ontario Votes 2007: Interview with Green candidate Marion Schaffer, Oakville
November 11th, 2022 | Uncategorized |

Monday, September 24, 2007

Marion Schaffer is running for the Green Party of Ontario in the Ontario provincial election, in the Oakville riding. Wikinews’ Nick Moreau interviewed her regarding her values, her experience, and her campaign.

Stay tuned for further interviews; every candidate from every party is eligible, and will be contacted. Expect interviews from Liberals, Progressive Conservatives, New Democratic Party members, Ontario Greens, as well as members from the Family Coalition, Freedom, Communist, Libertarian, and Confederation of Regions parties, as well as independents.

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Singapore police arrest death penalty book author

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Singapore police arrest death penalty book author
November 8th, 2022 | Uncategorized |

Tuesday, July 20, 2010

Singapore police arrested British author and journalist Alan Shadrake one day after the launch of his book about the country’s use of the death penalty.

Shadrake, 75, was arrested on Sunday morning at a hotel in Singapore and taken into custody by police on charges of criminal defamation, in response to a complaint lodged by the city-state’s Media Development Authority (MDA) over the contents of his new book, Once a Jolly Hangman: Singapore Justice in the Dock. Separately, the Attorney-General served Shadrake with an application for an order of committal for contempt of court, accusing him of “cast[ing] doubt on the impartiality, integrity, and independence” of Singapore’s courts through his book.

Shadrake’s latest book discusses alleged “double standards” in the country’s application of the death penalty, and contains interviews with local human rights activists, lawyers, and former police officers, including retired Changi Prison executioner Darshan Singh; Singh later claimed that he had been “tricked” into the interview. In earlier media comments, Shadrake stated that he expected “trouble” but no concrete action from authorities over his book, lest they draw even more attention to its claims. Retailers took his book off shelves after inquiries by the MDA; a spokesman for the MDA stated that the book was not banned, but suggested that booksellers “seek legal advice to ensure that the books they sell do not contravene Singapore laws”.

Shadrake has written for a variety of newspapers, including The Daily Telegraph of London as well as the New Straits Times of neighbouring Malaysia. His previous book, The Yellow Pimpernels, told the tale of various attempts to escape from East Germany over the Berlin Wall. If convicted, he faces a two-year imprisonment and a fine.

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Love Uniform Dating}

November 8th, 2022 | Clothing |

Love Uniform Dating

by

William Rogers

Got a thing for firemen? Or perhaps you’ve always wished marrying a nurse. Whatever your type, you’ll find it on uniform dating sites. These sites were set up specifically with uniformed personnel in mind. Typically, these people work awkward shift patterns or work faraway from home for hours of time which can have a bearing on long term human relationships.

[youtube]http://www.youtube.com/watch?v=YQ8Jdq_oY9E[/youtube]

Meeting like-minded personnel can take a great deal of the stress out of dating. The majority of the general public can’t know what goes into working in your industry. At uniform dating sites, you can meet people who not only understand your working patterns, they also truly appreciate why you do what you do. On most sites, you can sign up for free and even start contacting a person without having to pay anything. Arranging your profile is easy and stress free. You can begin sending communications or ‘flirts’ immediately. Yet, remember that if you prefer to access further features, you may need to pay a membership amount. You can even seek out people who work in your profession and therefore will understand precisely what you go through on a day-to-day basis. This support and understanding can help to make a nurturing bond between you that will last. Uniform dating is fast becoming one of the hottest new dating services. Even so it’s not just restricted to those who work in uniform, the sites are ready to accept everyone ( still, you must be over 18). If you do not work in uniform but you want to meet somebody who does, this is the place for you. The idea can be extremely alluring but do try to understand that they will usually have a great deal of responsibility and a tough work environment. As with all dating sites, remember your etiquette! Even if you are not curious about someone who contacts you, you must do the courteous thing and reply. Politely inform them of you aren’t interested and wish them luck in their continuing search. Also, when chatting for the very first time with someone, don’t ask too many personal questions. Keep it light and flirty – you can get to the juicy stuff later! Most especially, you must be truthful on your profile. Don’t upload photos that aren’t representative of exactly how you look and be honest about your hobbies and way of life. You will only finish up unclear and perchance hurting people, along with making your own life quite difficult in the act! If you plan to join up with somebody, make sure it is in a public, busy place. You must always keep your wits about you. Don’t be afraid to be a little bit guarded in the beginning: if your date is a common sense person, they will appreciate your caution and respect it. It’s a safe way to meet new people and enjoy yourself. The main site for sale encourages safety on dating in the modern world and keeps your info as private as you would like it to be. So get registered and enjoy yourself

Get connected to the virtual world of

uniform dating.com review

web sites sites and discover your love potential! Register on Free Dating Website or Dating Website to meet singles of your choice and get advice on falling in love. – http://www.loveshacksingles.com/

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French workers use threats in compensation demand">
French workers use threats in compensation demand

November 6th, 2022 | Uncategorized |

Friday, July 17, 2009Following similar threats by workers at New Fabris and Nortel, workers at JLG in Tonneins, France, threatened to blow up several platform cranes. The JLG factory announced in April 2009 that it will fire 53 of its 163 workers by the end of 2009, while the remaining 110 jobs will not be secure over the next 2 years.

JLG Tonneins was acquired in 2006 with its parent JLG Industries, a maker of aerial work platforms, by the U.S.-based Oshkosh Corporation. Despite being hugely profitable in the past, production has been much reduced since 2008 with the contraction of the construction industry and lower demand for its products. Despite excellent past results the new American management demanded sweeping cuts at the company.

In the view of locals, “the company’s actions are a disgrace given the expensive perks, such as official cars, for its corporate fat cats, compared to the sacrifice, silence, and dignity demanded by the company of those it has made redundant.”

The management offered severance pay of 3,000 (US $4,200), however the workers demanded a severance package commensurate with “the wealth that their labor has generated.” Worker’s delegates requested a “supra-legal” payment of € 30,000, on Thursday 16 of July the management responded with a counter offer of € 16,000. On Thursday night the worker’s actions secured the € 30,000 settlement initially demanded.

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Colleges offering admission to displaced New Orleans students/LA-ND">
Colleges offering admission to displaced New Orleans students/LA-ND

November 6th, 2022 | Uncategorized |
See the discussion page for instructions on adding schools to this list and for an alphabetically arranged listing of schools.

Due to the damage by Hurricane Katrina and subsequent flooding, a number of colleges and universities in the New Orleans metropolitan area will not be able to hold classes for the fall 2005 semester. It is estimated that 75,000 to 100,000 students have been displaced. [1]. In response, institutions across the United States and Canada are offering late registration for displaced students so that their academic progress is not unduly delayed. Some are offering free or reduced admission to displaced students. At some universities, especially state universities, this offer is limited to residents of the area.

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Category:June 9, 2010">
Category:June 9, 2010

November 5th, 2022 | Uncategorized |
? June 8, 2010
June 10, 2010 ?
June 9

Pages in category “June 9, 2010”

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How To Properly Water Your Lawn}

November 5th, 2022 | Irrigation |

Submitted by: Ti Grant Eckert

Lush green lawns are simply gorgeous-but it can take plenty of work to achieve that stunning emerald look. Watering your lawn correctly is absolutely vital to keeping your lawn healthy and green in any climate. Proper watering of your lawn can even help preserve water, as you’ll be using it more efficiently, with less waste.

When and How to Water

You don’t necessarily need to start watering your lawn as soon as the first few warm summer days appear. You’ll actually achieve a healthier lawn, with a more extensive and deep root system, if you hold off watering until your lawn begins to enter a mild state of drought. When your lawn begins to enter this state, the grass will turn a darker shade of green, and footprints made when you walk across the lawn will remain imprinted, instead of the blades quickly bouncing back up.

If you’re able to, watering your lawn early in the day is best. Midday watering is inefficient and may be detrimental to your lawn, as moisture will evaporate quickly at this time. Watering in the evening can help cultivate lawn diseases, as the grass will remain damp for longer periods. However, if you live in a very hot climate, watering during the evening is preferable, as less moisture will be lost due to evaporation, and temperatures will not be cold enough to prevent grass blades drying completely overnight.

One of thee most important points in watering your lawn is ensuring that you maintain an even distribution of water over the entire lawn, and that no spot is either missed or flooded with excess water.

[youtube]http://www.youtube.com/watch?v=-mk8ELQnu-E[/youtube]

The best way to achieve this objective is with a sprinkler system, rather than with a hose. To ensure your system is providing even coverage over your lawn, place some empty cans or other straight-sided containers at various spots over the lawn, and then check how much water each contains after a watering session.

How Much Water?

Thorough, less frequent watering is much more efficient-and healthy for your lawn-than frequent, light watering. A good, heavy watering that penetrates deep into the soil helps to promote a healthy root system, and also discourages the growth of weeds.

In normal conditions, grasses need between three quarters of an inch and one full inch of water per week to maintain that rich green color, and to keep the lawn healthy and actively growing, as well as attractive. In very hot climates, more frequent watering may be needed. Check your lawn for blade ‘bounce’ to ensure your lawn receives enough water.

Remember that this requirement includes both precipitation (rain) and watering. If you receive an inch of rainfall in any given week, you can hold off watering until it’s needed. In addition, it’s important to realize that this one inch isn’t an absolute requirement-your lawn won’t sicken and die if it doesn’t get an inch every week, but too much water in a short time can be harmful. If, for example, you know rain is expected very soon, you can safely hold off watering until after the rain arrives.

How Long?

Each watering of your lawn should provide plenty of water for the active root zone of the grass. The length of time this takes depends on the type of watering system you use, and the type of soil you have. In general, most types of grass need to be soaked to a depth of eight to twelve inches. Some grasses, such as bluegrass, need to be soaked to a depth of six to eight inches.

To calculate how long you’ll need to run your sprinkler system to achieve the right depth, do the following:

1. Run your sprinkler system for fifteen minutes.

2. After 24 hours, drive a screwdriver or other implement into the earth to check how deep the water penetrated. You’ll be able to drive the implement easily through moist soil, but once you hit dry soil it will become difficult.

3. Divide 120 by the depth of moist soil you determined in step 2. If the water soaked in to a depth of three inches, for example, you’ll end up with a figure of 40 minutes. That means it will take two hours for the lawn to be soaked to a depth of nine inches, and two hours and forty minutes to get soaked to a depth of twelve inches.

Water Conservation Tips

If you live in a climate that routinely achieves very high temperatures during the summer, consider letting your lawn go dormant as an alternative to watering.

Purchase a rain gauge so that you can determine how much rain your lawn receives, and avoid over-watering.

Aerate your lawn to allow the grass to use water more efficiently.

About the Author: Grant Eckert is a freelance writer who writes about topics pertaining to home maintenance such as

trugreen.com/

Lawn Care

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Wikinews Shorts: July 9, 2007">
Wikinews Shorts: July 9, 2007

November 5th, 2022 | Uncategorized |

A compilation of brief news reports for Monday, July 9, 2007.

On July 9, 2007, Sony Computer Entertainment America announced the release of an 80GB hard drive version of its PlayStation 3 video game console, priced at US$599.

Sony also announced a price drop to US$499 for its current 60GB model. Jack Tretton, Sony Entertainment America chief executive, said, “Our initial expectation is that sales should double at a minimum.”

Sources


Nigerian gunmen have released three-year-old Margaret Hill, after holding her captive for four days. The toddler has since been reunited with her parents. She is reportedly in good health but covered with mosquito bites and also hungry, having not eaten recently.

The kidnappers had threatened to kill the toddler unless a ransom was paid or Mr. Hill came to take her place. The family claims no ransom was paid for her freedom. She was kidnapped from her car on July 5, on her way to school. Her driver was stabbed trying to protect Margaret.

Sources


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